Creatinine clearance (Cockcroft–Gault)
Estimates creatinine clearance for renal drug dosing, with every dosing weight compared side by side.
Inputs
0 of 4SexUsed by the equation
Original equation multiplies by 0.85 for female sex
years
Actual (total) body weight
Stable value
Optional, for ideal and adjusted weight
When to use
- Adults with stable kidney function, when a drug's labeling gives dose adjustments by CrCl.
- Add height to compare actual, ideal, and adjusted body weight in one view.
Pearls and pitfalls
- Not valid in unstable or rapidly changing kidney function (AKI), dialysis, or pregnancy.
- Overestimates in low muscle mass (older adults, amputees, malnutrition) and can mislead at weight extremes.
- Many labels were written with CrCl from Cockcroft–Gault, not eGFR. Use what the label used.
- Rounding SCr up to 0.8 or 1.0 mg/dL is an institutional practice and is not applied here.
Why use
Which weight to use in Cockcroft–Gault is contested. Instead of picking one silently, ClinDose shows all three and a BMI-guided estimate with its functional range (Brown 2013, Winter 2012), so you can apply your institution's policy.
- where
- CrCl
- Creatinine clearance, mL/min
- Age
- Years
- Weight
- kg (actual, ideal, or adjusted)
- SCr
- Serum creatinine, mg/dL
- F
- 0.85 if female, 1 if male