International Staging System for multiple myeloma
Myeloma stage from beta-2 microglobulin and albumin.
Inputs
0 of 2mg/L
When to use
- Newly diagnosed myeloma.
Pearls and pitfalls
- R-ISS adds LDH and high-risk cytogenetics; R2-ISS refines further.
Why use
Universal myeloma staging.
Stage I: β₂M < 3.5 mg/L and albumin ≥ 3.5 g/dL; stage III: β₂M ≥ 5.5 mg/L; otherwise stage II