PLASMIC score for TTP
Probability of severe ADAMTS13 deficiency in suspected thrombotic microangiopathy.
Inputs
Platelets below 30 × 10⁹/L
Hemolysis (reticulocytes above 2.5%, undetectable haptoglobin, or indirect bilirubin above 2 mg/dL)
No active cancer
No solid organ or stem cell transplant
MCV below 90 fL
INR below 1.5
Creatinine below 2.0 mg/dL
Worked calculation
Your values are highlighted.
- Points
When to use
- Microangiopathic hemolytic anemia with thrombocytopenia.
Pearls and pitfalls
- High scores support starting plasma exchange while ADAMTS13 results are pending.
Why use
Guides urgent plasma exchange.
| Criterion | Points |
|---|---|
| Platelets below 30 × 10⁹/L | +1 |
| Hemolysis (reticulocytes above 2.5%, undetectable haptoglobin, or indirect bilirubin above 2 mg/dL) | +1 |
| No active cancer | +1 |
| No solid organ or stem cell transplant | +1 |
| MCV below 90 fL | +1 |
| INR below 1.5 | +1 |
| Creatinine below 2.0 mg/dL | +1 |