Calculated osmolality and osmolal gap

Calculated serum osmolality and the gap versus measured, for toxic alcohols.

Previewv0.1.0 · Pending clinical review

Inputs

0 of 3
mEq/L
Optional
mg/dL
Optional
mOsm/kg
When to use
  • Suspected toxic alcohol ingestion.
  • Unexplained high anion gap acidosis.
Pearls and pitfalls
  • A normal gap does not exclude toxic alcohol ingestion, especially late.
  • Ethanol divisor of 3.7 is commonly used; some sources use 4.6.
Why use

Includes ethanol so the gap is not falsely raised.

Osm=2×Na+Glu18+BUN2.8+EtOH3.7
Gap=Osmmeasured−Osm
where
Na
Sodium, mEq/L
Glu
Glucose, mg/dL
BUN
Blood urea nitrogen, mg/dL
EtOH
Ethanol, mg/dL

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