Theophylline and aminophylline loading dose
Loading dose to reach a target level, as theophylline or aminophylline.
Inputs
2 of 5SexUsed by the equation
Actual (total) body weight
mg/L
mg/L
Patient values are shared with every calculator.
When to use
- Loading theophylline or aminophylline (rarely needed today).
Pearls and pitfalls
- Target 5–15 mg/L for most adults (label); toxicity rises above 20.
- Smoking, rifampin, and phenytoin increase clearance; heart failure, liver disease, ciprofloxacin, and erythromycin decrease it.
Why use
Handles the salt factor and the level already on board.
Load (theophylline) = 0.5 L/kg × IBW × (target − current); aminophylline = theophylline ÷ 0.8