Heparin
Dosing in kidney impairment
Extracorporeal Dialysis Follow equipment manufacturer's operating directions carefully. A dose of 25 units/kg to 30 units/kg followed by an infusion rate of 1,500 units/hour to 2,000 units/hour is suggested based on pharmacodynamic data if specific manufacturers' recommendations are not available.
| For pediatric dosing see section 2.4 of full prescribing information. | |
| Intravascular via Extracorporeal Dialysis | Follow equipment manufacturer's operating directions carefully. |
Preparation and administration
Preparation for Administration Confirm the selection of the correct formulation and strength prior to administration of the drug. Do not use HEPARIN SODIUM IN SODIUM CHLORIDE INJECTION as a "catheter lock flush" product. Administer this product by intravenous infusion. Do not admix with other drugs. This product should not be infused under pressure.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not administer unless the solution is clear and container is undamaged. Discard unused portion. To Open Tear outer wrap and remove solution container. For PVC bags, some opacity of the plastic due to moisture absorption during the sterilization process may be observed.
This is normal and does not affect the solution quality or safety. The opacity will diminish gradually. (Use aseptic technique) 1. Close flow control clamp of administration set. 2. Remove cover from outlet port at bottom of container. 3. Insert piercing pin of administration set into port with a twisting motion until the set is firmly seated.
NOTE: See full directions on administration set carton. 4. Suspend container from hanger. 5. Squeeze and release drip chamber to establish proper fluid level in chamber. 6. Open flow control clamp and clear air from set. Close clamp. 7. Attach set to venipuncture device. If device is not indwelling, prime and make venipuncture. 8.
Regulate rate of administration with flow control clamp. Warning: Do not use flexible container in series connections.
| Intermittent Intravenous Injection | Initial Dose | 10,000 Units |
| Every 4 to 6 hours | 5,000 Units to 10,000 Units | |
| Continuous Intravenous Infusion | Initial Dose | 5,000 Units |
| Continuous | 20,000 Units to 40,000 Units/24 hours | |
| *Based on 150 lb (68 kg) patient. | ||
| Method of Administration | Frequency | Recommended DoseBased on 150 lb. (68 kg) patient. |
| Intermittent Intravenous Injection | Initial Dose | 10,000 Units |
| Every 4 to 6 hours | 5,000 Units to 10,000 Units | |
| Continuous Intravenous Infusion | Initial Dose | 5,000 Units by intravenous injection |
| Continuous | 20,000 Units/24 hours to 40,000 Units/24 hours |
| Initial Dose | 75 units/kg to 100 units/kg (intravenous bolus over 10 minutes) |
| Maintenance Dose | Infants: 25 units/kg/hour to 30 units/kg/hour (continuous intravenous infusion); Infants less than 2 months have the highest requirements (average 28 units/kg/hour) Children greater than 1 year of age: 18 units/kg/hour to 20 units/kg/hour (continuous intravenous infusion); Older children may require less heparin, similar to weight-adjusted adult dosage. |
| Monitoring | Adjust heparin to maintain APTT of 60 seconds to 85 seconds, assuming this reflects an anti-Factor Xa level of 0.35 to 0.70. |