Insulin lispro
Dosing in kidney impairment
Renal Impairment The effect of renal impairment on the pharmacokinetics of HUMALOG Mix50/50 has not been studied. Patients with renal impairment may be at increased risk of hypoglycemia and may require more frequent HUMALOG Mix50/50 dose adjustment and more frequent glucose monitoring [see Warnings and Precautions] .
Dosing in liver impairment
Hepatic Impairment The effect of hepatic impairment on the pharmacokinetics of HUMALOG Mix50/50 has not been studied. Patients with hepatic impairment may be at increased risk of hypoglycemia and may require more frequent HUMALOG Mix50/50 dose adjustment and more frequent glucose monitoring [see Warnings and Precautions] .
Preparation and administration
Important Preparation and Administration Instructions Preparation Instructions Always check insulin labels before administration [see Warnings and Precautions] . HUMALOG Mix50/50 is a suspension that must be resuspended immediately before use. Resuspension is easier when the insulin has reached room temperature. To resuspend the KwikPen, gently roll the KwikPen at least 10 times and then carefully invert the KwikPen at least 10 times until the suspension appears uniformly white and cloudy.
Inspect HUMALOG Mix50/50 visually before use. Do not use if discoloration or particulate matter is seen. Administration Instructions After resuspension, immediately administer HUMALOG Mix50/50 by subcutaneous injection into the abdominal wall, thigh, upper arm, or buttocks. Rotate the injection site within the same region from one injection to the next to reduce the risk of lipodystrophy and localized cutaneous amyloidosis.
Do not inject into areas of lipodystrophy or localized cutaneous amyloidosis [see Warnings and Precautions and Adverse Reactions] . The HUMALOG Mix50/50 KwikPen dials in 1 unit increments. Use HUMALOG Mix50/50 KwikPen with caution in patients with visual impairment that may rely on audible clicks to dial their dose. Do not administer HUMALOG Mix50/50 intravenously or by a continuous subcutaneous insulin infusion pump.
Do not mix HUMALOG Mix50/50 with any other insulins or diluents.