Colistin (colistimethate) dosing
Loading and maintenance doses in colistin base activity by creatinine clearance, per international consensus.
Inputs
0 of 5SexUsed by the equation
years
Actual (total) body weight
Stable value
When to use
- Systemic colistimethate for multidrug-resistant gram-negative infection.
Pearls and pitfalls
- Products are labeled in CBA (US) or international units (Europe); confirm before ordering.
- Polymyxin B is preferred for systemic infections outside the urinary tract (consensus).
- Dialysis and CRRT need separate supplemental dosing.
Why use
Converts between CBA and IU and applies the consensus renal table.
Loading 300 mg CBA; daily maintenance from the CrCl table, divided every 12 hours; 1 million IU CMS ≈ 33.3 mg CBA