DOAC dosing in atrial fibrillation
Label dose of apixaban, rivaroxaban, dabigatran, or edoxaban for stroke prevention, from kidney function, age, and weight.
Inputs
1 of 5SexUsed by the equation
years
Actual (total) body weight
Stable value
Drug
Patient values are shared with every calculator.
When to use
- Nonvalvular atrial fibrillation stroke prevention.
Pearls and pitfalls
- Underdosing is common and raises stroke risk; dose reduce only when label criteria are met.
- Apixaban reduction uses age, weight, and creatinine, not CrCl.
- Check interacting drugs (strong CYP3A4/P-gp inhibitors and inducers).
Why use
Applies each label's exact criteria to the patient's values.
Label criteria per drug; CrCl by Cockcroft-Gault with actual body weight (as in the pivotal trials)