Lille model (steroid response in alcohol-associated hepatitis)
Day-7 assessment of response to corticosteroids.
Inputs
1 of 6years
Creatinine above 1.3 mg/dL
seconds
Patient values are shared with every calculator.
When to use
- Day 7 of corticosteroids for severe alcohol-associated hepatitis.
Pearls and pitfalls
- 0.45 or more: non-response; stopping steroids is generally advised.
- Renal insufficiency is creatinine above 1.3 mg/dL.
Why use
Avoids continuing ineffective steroids.
R = 3.19 − 0.101 × age + 0.147 × albumin (g/L) + 0.0165 × (bili day 0 − day 7, µmol/L) − 0.206 × renal − 0.0065 × bili day 0 − 0.0096 × PT; Lille = e^(−R) ÷ (1 + e^(−R))