Maddrey discriminant function (alcohol-associated hepatitis)
Identifies severe alcohol-associated hepatitis that may benefit from corticosteroids.
Inputs
1 of 3seconds
seconds
When to use
- Suspected alcohol-associated hepatitis.
Pearls and pitfalls
- DF 32 or more: severe; consider prednisolone 40 mg/day if no contraindication.
- MELD above 20 is an alternative severity threshold.
- Reassess response with the Lille score on day 7.
Why use
The classic steroid-eligibility threshold.
DF = 4.6 × (patient PT − control PT) + total bilirubin (mg/dL)