MASCC risk index for febrile neutropenia
Identifies low-risk febrile neutropenia suitable for outpatient management.
Inputs
0 of 1Burden of illness
No hypotension (SBP 90 or higher)
No COPD
Solid tumor, or hematologic malignancy without previous fungal infection
No dehydration needing IV fluids
Outpatient at fever onset
Age under 60
When to use
- Adults with febrile neutropenia.
Pearls and pitfalls
- 21 or higher is low risk; consider oral antibiotics (for example, fluoroquinolone plus amoxicillin-clavulanate) and outpatient care if other criteria allow.
- Use CISNE for clinically stable solid-tumor patients.
Why use
The guideline-endorsed risk index.
| Criterion | Points |
|---|---|
| Burden of illness: No or mild symptoms | +5 |
| Moderate symptoms | +3 |
| Severe symptoms or moribund | 0 |
| No hypotension (SBP 90 or higher) | +5 |
| No COPD | +4 |
| Solid tumor, or hematologic malignancy without previous fungal infection | +4 |
| No dehydration needing IV fluids | +3 |
| Outpatient at fever onset | +3 |
| Age under 60 | +2 |