Transferrin saturation (TSAT)

Percent of transferrin bound to iron, from serum iron and TIBC.

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When to use
  • Iron deficiency workup, especially in CKD.
Pearls and pitfalls
  • Below 20% suggests iron deficiency; above 45% suggests iron overload.
  • Ferritin is an acute-phase reactant; interpret together.
Why use

A quick check before IV iron or ESA therapy.

TSAT (%) = serum iron ÷ TIBC × 100

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