Warfarin initiation nomogram (5 mg)

Day 3 to 6 doses by INR after starting warfarin 5 mg on days 1 and 2.

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Therapy day
When to use
  • Starting warfarin with parenteral anticoagulant overlap (typical VTE treatment).
Pearls and pitfalls
  • Start lower (2.5 mg or less) in older, frail, or malnourished patients, liver disease, heart failure, or interacting drugs.
  • Continue the parenteral anticoagulant at least 5 days and until INR is 2 or more for 24 hours.
  • A 10 mg start is an option for healthy outpatients (ACCP).
Why use

The published day-by-day table, so doses are consistent across the team.

Days 1–2: 5 mg; days 3–6: dose from the INR band for that day

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