Ampicillin

Preview FDA label, Meitheal Pharmaceuticals Inc., intravenous, effective 2026-07-23. Full label on DailyMed

Quoted from the FDA label. Product labels differ by manufacturer and change over time; confirm against the label for the product you are using. Not yet reviewed by a ClinDose pharmacist.

Dosing in kidney impairment

In clinical trials, most pediatric patients received a course of oral antimicrobials following initial treatment with intravenous ampicillin and sulbactam for injection (see CLINICAL STUDIES section). Impaired Renal Function In patients with impairment of renal function the elimination kinetics of ampicillin and sulbactam are similarly affected, hence the ratio of one to the other will remain constant whatever the renal function.

The dose of ampicillin and sulbactam for injection in such patients should be administered less frequently in accordance with the usual practice for ampicillin and according to the following recommendations: [See table below.] When only serum creatinine is available, the following formula (based on sex, weight, and age of the patient) may be used to convert this value into creatinine clearance.

The serum creatinine should represent a steady state of renal function. Males Weight (kg) x (140 - age) 72 x serum creatinine Females 0.85 x above value

TABLE 3:
Ampicillin And Sulbactam For Injection Dosage Guide for Patients with Renal Impairment
Creatinine Clearance (mL/min/1.73m2)Ampicillin and Sulbactam Half-Life (Hours)Recommended Ampicillin And Sulbactam For Injection Dosage
≥3011.5 g to 3 g every 6 to 8 hours
15 to 2951.5 g to 3 g every 12 hours
5 to 1491.5 g to 3 g every 24 hours

Preparation and administration

DOSAGE AND ADMINISTRATION Ampicillin and sulbactam for injection may be used for parenteral administration. THE INTENT OF THIS PHARMACY BULK PACKAGE IS FOR PREPARATION OF SOLUTIONS FOR IV INFUSION ONLY. Ampicillin and sulbactam for injection should be administered diluted with 50 to 100 mL of a compatible diluent as an intravenous infusion over 15 to 30 minutes.

The total dose of sulbactam should not exceed 4 g per day. Pediatric Patients 1 Year of Age or Older: The recommended daily dose of ampicillin and sulbactam for injection in pediatric patients is 300 mg per kg of body weight administered via intravenous infusion in equally divided doses every 6 hours. This 300 mg/kg/day dosage represents the total ampicillin content plus the sulbactam content of ampicillin and sulbactam for injection, and corresponds to 200 mg ampicillin and 100 mg sulbactam per kg per day.

Calculators for ampicillin