Atovaquone and proguanil
Dosing in kidney impairment
Renal Impairment Do not use atovaquone and proguanil hydrochloride tablets for malaria prophylaxis in patients with severe renal impairment (creatinine clearance <30 mL/min) [See Contraindications] . Use with caution for the treatment of malaria in patients with severe renal impairment, only if the benefits of the 3 day treatment regimen outweigh the potential risks associated with increased drug exposure.
No dosage adjustments are needed in patients with mild (creatinine clearance 50 to 80 mL/min) or moderate (creatinine clearance 30 to 50 mL/min) renal impairment. [See Clinical Pharmacology.
Dosing in liver impairment
Hepatic Impairment No dosage adjustments are needed in patients with mild or moderate hepatic impairment [see Clinical Pharmacology] . No trials have been conducted in patients with severe hepatic impairment