Capecitabine
Dosing in kidney impairment
Dosage Modification For Renal Impairment Reduce the dose of capecitabine tablet by 25% for patients with creatinine clearance (CLcr) of 30 to 50 mL/min as determined by Cockcroft-Gault equation. A dosage has not been established in patients with severe renal impairment (CLcr <30 mL/min) [see Use in Specific Populations ].
Dosing in liver impairment
Hepatic Impairment The exposure of capecitabine increases in patients with mild to moderate hepatic impairment. The effect of severe hepatic impairment on the safety and pharmacokinetics of capecitabine is unknown [see Clinical Pharmacology ]. Monitor patients with hepatic impairment more frequently for adverse reactions.
Preparation and administration
Administration Round the recommended dosage for patients to the nearest 150 mg dose to provide whole capecitabine tablets. Swallow capecitabine tablets whole with water within 30 minutes after a meal. Do not chew, cut, or crush capecitabine tablets [see Warnings and Precautions ]. Take capecitabine tablets at the same time each day approximately 12 hours apart.
Do not take an additional dose after vomiting and continue with the next scheduled dose. Do not take a missed dose and continue with the next scheduled dose. Capecitabine tablet is a hazardous drug. Follow applicable special handling and disposal procedures. 1