Cefadroxil
Quoted from the FDA label. Product labels differ by manufacturer and change over time; confirm against the label for the product you are using. Not yet reviewed by a ClinDose pharmacist.
Dosing in kidney impairment
In the treatment of beta-hemolytic streptococcal infections, a therapeutic dosage of cefadroxil should be administered for at least 10 days. Renal Impairment In patients with renal impairment, the dosage of cefadroxil should be adjusted according to creatinine clearance rates to prevent drug accumulation. The following schedule is suggested.
In adults, the initial dose is 1000 mg of cefadroxil and the maintenance dose (based on the creatinine clearance rate [mL/min/1.73 m 2 ]) is 500 mg at the time intervals listed below. [See table below.] Patients with creatinine clearance rates over 50 mL/min may be treated as if they were patients having normal renal function.
| Creatinine Clearances | Dosage Interval |
|---|---|
| 0 to 10 mL/min | 36 hours |
| 10 to 25 mL/min | 24 hours |
| 25 to 50 mL/min | 12 hours |