Clevidipine
Dosing in kidney impairment
In clinical trials, 78 patients with abnormal hepatic function (one or more of the following: elevated serum bilirubin, AST/SGOT, ALT/SGPT) and 121 patients with moderate to severe renal impairment were treated with Cleviprex. An initial Cleviprex infusion rate of 1-2 mg/hour is appropriate in these patients. Table 1 is a guideline for dosing conversion from mg/hour to mL/hour. [See table below.] 2.3 Instructions for Administration Maintain aseptic technique while handling Cleviprex.
Preparation and administration
Monitoring Monitor blood pressure and heart rate continually during infusion, and then until vital signs are stable. Patients who receive prolonged Cleviprex infusions and are not transitioned to other antihypertensive therapies should be monitored for the possibility of rebound hypertension for at least 8 hours after the infusion is stopped.
These patients may need follow-up adjustments in blood pressure control.
Instructions for Administration Maintain aseptic technique while handling Cleviprex. Cleviprex is a single-use parenteral product. Do not use if contamination is suspected. Once the stopper is punctured, use within 12 hours and discard any unused portion. Cleviprex is supplied in sterile, pre-mixed, ready-to-use 50 mL, or 100 mL, or 250 mL vials.
Invert vial gently several times before use to ensure uniformity of the emulsion prior to administration. Inspect parenteral drug products for particulate matter and discoloration prior to administration whenever solution and container permit. Administer Cleviprex using an infusion device allowing calibrated infusion rates.
Commercially available standard plastic cannulae may be used to administer the infusion. Administer Cleviprex by a central line or a peripheral line. Cleviprex should not be administered in the same line as other medications. Cleviprex should not be diluted, but it can be administered with the following: Water for Injection, USP Sodium Chloride (0.9%) Injection, USP Dextrose (5%) Injection, USP Dextrose (5%) in Sodium Chloride (0.9%) Injection, USP Dextrose (5%) in Ringers Lactate Injection, USP Lactated Ringers Injection, USP 10% amino acid