Febuxostat
Dosing in kidney impairment
Dosage Recommendations in Patients with Renal Impairment and Hepatic Impairment The recommended dosage of febuxostat tablets is limited to 40 mg once daily in patients with severe renal impairment. No dose modification is necessary when administering febuxostat tablets in patients with mild or moderate renal impairment [see Use in Specific Populations and Clinical Pharmacology ] .
No dosage modification is necessary in patients with mild to moderate hepatic impairment [see Use in Specific Populations and Clinical Pharmacology ] .
Dosing in liver impairment
Hepatic Impairment No dose adjustment is necessary in patients with mild or moderate hepatic impairment (Child-Pugh Class A or B). No studies have been conducted in patients with severe hepatic impairment (Child-Pugh Class C); therefore, caution should be exercised in these patients [see Clinical Pharmacology ].