Hydroxyurea
Quoted from the FDA label. Product labels differ by manufacturer and change over time; confirm against the label for the product you are using. Not yet reviewed by a ClinDose pharmacist.
Dosing in kidney impairment
Dose Modifications for Renal Impairment Reduce the dose of hydroxyurea capsules by 50% in patients with measured creatinine clearance of less than 60 mL/min or with end-stage renal disease (ESRD) [see Use in Specific Populations and Clinical Pharmacology ]. [See table below.] Close monitoring of hematologic parameters is advised in these patients.
| Creatinine Clearance(mL/min) | Recommended HydroxyureaCapsules Initial Dose(mg/kg once daily) |
| ≥60 | 15 |
| <60 or ESRD* | 7.5 |
| *On dialysis days, administer hydroxyurea capsules to patients following hemodialysis. | |
Dosing in liver impairment
Hepatic Impairment There are no data that support specific guidance for dosage adjustment in patients with hepatic impairment. Close monitoring of hematologic parameters is advised in these patients.