Lenalidomide
Dosing in kidney impairment
Recommended Dosage for Patients with Renal Impairment The recommendations for dosing patients with renal impairment are shown in the following table [see Clinical Pharmacology ] . Table 3: Dose Adjustments for Patients with Renal Impairment [See table below.] 2.5 mg once daily. On dialysis days, administer the dose following dialysis.
Lenalidomide Capsules Combination Therapy for MM: For CL cr of 30 mL/min to 60 mL/min, consider escalating the dose to 15 mg after 2 cycles if the patient tolerates the 10 mg dose of lenalidomide without dose-limiting toxicity. Lenalidomide Capsules Maintenance Therapy Following Auto-HSCT for MM: Base subsequent lenalidomide capsules dose increase or decrease on individual patient treatment tolerance [see Dosage and Administration ] .
| Renal Function(Cockcroft-Gault) | Dose in Lenalidomide Capsules Combination Therapy for MM | Dose in Lenalidomide Capsules Maintenance Therapy Following Auto-HSCT for MM |
| CLcr 30 mL/min to 60 mL/min | 10 mg once daily | 5 mg once daily |
| CLcr below 30 mL/min (not requiring dialysis) | 15 mg every other day | 2.5 mg once daily |
| CLcr below 30 mL/min (requiring dialysis) | 5 mg once daily. On dialysis days, administer the dose following dialysis. | 2.5 mg once daily. On dialysis days, administer the dose following dialysis. |
Preparation and administration
Administration Advise patients to take lenalidomide capsules orally at about the same time each day, either with or without food. Advise patients to swallow lenalidomide capsules whole with water and not to open, break, or chew them.