Terbinafine
Quoted from the FDA label. Product labels differ by manufacturer and change over time; confirm against the label for the product you are using. Not yet reviewed by a ClinDose pharmacist.
Dosing in kidney impairment
Renal Impairment In patients with renal impairment (creatinine clearance less than or equal to 50 mL/min), the use of terbinafine tablets has not been adequately studied.
Dosing in liver impairment
Hepatic Impairment Terbinafine tablets are contraindicated for patients with chronic or active liver disease [see Contraindications and Warnings and Precautions] . Cases of liver failure, some leading to liver transplant or death, have occurred with the use of terbinafine tablets in individuals with and without preexisting liver disease.
The severity of hepatic events and/or their outcome may be worse in patients with active or chronic liver disease.