Tranexamic acid
Dosing in kidney impairment
Recommended Dosage for Patients With Varying Degrees of Renal Impairment For patients with moderate to severe impaired renal function, the following dosages are recommended: Table 1. Recommended Dosage in Patients With Varying Degrees of Renal Impairment* [See table below.]
Preparation and administration
Preparation and Administration Tranexamic acid injection is for intravenous administration only. Tranexamic acid injection can be administered undiluted or as a diluted solution. Use aseptic technique to prepare tranexamic acid injection. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
Tranexamic acid injection is a clear and colorless solution. Discard the vial if particulate matter is observed. Calculate the dose (mg) based on the patient’s actual body weight and the total volume (mL) of tranexamic acid injection solution required. If diluting tranexamic acid injection , follow the instructions below: From the diluent infusion bag, withdraw a volume equal to the volume of the tranexamic acid injection solution required for the patient’s dose.
Withdraw the required volume of tranexamic acid injection solution from the vial and dilute with a compatible diluent (see below) to make a final concentration of 10 mg/mL or 20 mg/mL. Discard any unused portion left in the vial. For intravenous infusion, tranexamic acid injection may be mixed with most solutions for infusion such as electrolyte solutions, carbohydrate solutions, amino acid solutions, and Dextran solutions.
Heparin may be added to tranexamic acid injection. Tranexamic acid injection should NOT be mixed with blood. The drug is a synthetic amino acid and should NOT be mixed with solutions containing penicillin. Gently invert the infusion bag to mix the diluted solution. DO NOT SHAKE. If not used immediately, store the diluted tranexamic acid injection infusion solution at room temperature 20ºC to 25°C (68ºF to 77°F) for up to 4 hours.
Administration Infuse undiluted solution no more than 1 mL/minute to avoid hypotension [see Adverse Reactions ] . Administer the undiluted and diluted solutions intravenously according to Table 2 Table 2. Administration Rates for Undiluted and Diluted Solutions [See table below.]
| Undiluted solution | Diluted solution | ||
| Final concentration | 100 mg/mL | 10 mg/mL | 20 mg/mL |
| Administration rate | 0.5 mL/minute (no more than1 mL/minute) | 5 mL/minute | 2.5 mL/minute |