Diatrizoate
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From MedlinePlus, U.S. National Library of Medicine
Dosing in kidney impairment
This label has no separate kidney-impairment dosing section. Check warnings and clinical pharmacology in the full label.
Preparation and administration
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Best results are obtained when the bladder is filled with the contrast agent. If desired, the preparation may be diluted with sterile water or sterile saline as indicated in the table below. Administration: After sterile catheterization, the bladder should be filled to capacity with Cystografin using a suitable sterile administration set.
| USE DILUTED SOLUTIONS IMMEDIATELY | |||
| 100 mL Bottle | |||
| Sterile Water or Sterile Saline Added | % Diatrizoate Meglumine w/v | % Organically Bound Iodine w/v | Total Volume |
| 0 mL | 30.0 | 14.1 | 100 mL |
| 25 mL | 24.0 | 11.3 | 125 mL |
| 50 mL | 20.0 | 9.4 | 150 mL |
| 67 mL | 18.0 | 8.5 | 167 mL |
| 300 mL Bottle | |||
| Sterile Water or Sterile Saline Added | |||
| 0 mL | 30.0 | 14.1 | 300 mL |
| 50 mL | 25.7 | 12.1 | 350 mL |
Contraindications
This preparation is contraindicated in patients with a hypersensitivity to salts of diatrizoic acid.
Safety data
Reported adverse events (FAERS)
Liver injury (LiverTox)
LiverTox has no chapter for diatrizoate. Check the label's hepatic warnings.
Pregnancy and lactation
Pregnancy
Pregnancy—Teratogenic Effects: Animal reproduction studies have not been conducted with diatrizoate meglumine injection. It is also not known whether diatrizoate meglumine injection can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Cystografin should be administered to a pregnant woman only if clearly needed.
Breastfeeding (LactMed)
Limited information indicates that maternal doses of diatrizoate up to 38 g (containing 18.5 grams of iodine) produce low levels in milk. In addition, because diatrizoate is poorly absorbed orally, it is not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants. Guidelines developed by several professional organizations state that breastfeeding need not be disrupted after a nursing mother receives an iodine-containing contrast medium.-
Supply and cost
Drug shortage status
Recalls (last 24 months)
Therapeutic equivalence (Orange Book)
Price ladder
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