Nitric oxide
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From MedlinePlus, U.S. National Library of Medicine
Vasodilator
Dosing in kidney impairment
This label has no separate kidney-impairment dosing section. Check warnings and clinical pharmacology in the full label.
Dosing in liver impairment
Administration Nitric Oxide Delivery Systems INOmax must be administered using a calibrated, FDA-cleared Nitric Oxide Delivery System (NODS). There are various FDA-cleared NODS; refer to the NODS labeling to determine which NODS to use with this drug product and for needed information on training and technical support for users of this drug product with the NODS.
When utilizing a nitric oxide delivery system specifically cleared for use in the MRI suite (e.g., the INOmax DSIR ® Plus MRI) only use INOmax MR conditional cylinders at 100 gauss or less [see How Supplied/Storage and Handling ]. Keep available a backup battery power supply and an independent reserve nitric oxide delivery system to address power and system failures .
Monitoring Measure methemoglobin within 4-8 hours after initiation of treatment with INOmax and periodically throughout treatment [see Warnings and Precautions ] . Monitor for PaO 2 and inspired NO 2 during INOmax administration [see Warnings and Precautions ] . Weaning and Discontinuation Avoid abrupt discontinuation of INOmax [see Warnings and Precautions ].
To wean INOmax, downtitrate in several steps, pausing several hours at each step to monitor for hypoxemia.
Drug interactions
Check nitric oxide against a medication listLabel text (2 paragraphs)
Nitric oxide donor compounds may increase the risk of developing methemoglobinemia ( 7 ).
7.1 Nitric Oxide Donor Agents Nitric oxide donor agents such as prilocaine, sodium nitroprusside and nitroglycerine may increase the risk of developing methemoglobinemia.
Contraindications
4 CONTRAINDICATIONS INOmax is contraindicated in neonates dependent on right-to-left shunting of blood. Neonates dependent on right-to-left shunting of blood ( 4 ).
Supply and cost
Drug shortage status
Recalls (last 24 months)
Therapeutic equivalence (Orange Book)
Price ladder
Not the price at the counterThese are not what a patient pays at the pharmacy counter. They are what pharmacies, health plans, and government buyers pay, before manufacturer rebates. A patient's cost depends on their insurance (copay, coinsurance, or deductible) or the pharmacy's cash price.