Sodium iodide i-123

FDA label, Curium US LLC, oral, effective 2024-10-17. Full label on DailyMed

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From MedlinePlus, U.S. National Library of Medicine

Quoted from the FDA label. Product labels differ by manufacturer and change over time; confirm against the label for the product you are using.

Dosing in kidney impairment

This label has no separate kidney-impairment dosing section. Check warnings and clinical pharmacology in the full label.

Preparation and administration

Table 4. Absorbed Radiation Dose Estimates as a Function of Maximum Thyroid Uptake for Sodium Iodide I-123 ^*at Time of Calibration and Expiry Compared to Sodium Iodide I-131
		Estimated Radiation Absorbed Doses
		I-123 mGy/14.8 MBq (rads/400 μCi)		I-131 mGy/3.7 MBq (rads/100 μCi)
Target Organ	Maximum Thyroid Uptake (%)	TOC	TOE
^*Concentration at Time of Calibration: 97% I-123, 2.9% I-125, 0.1% Te-121
Concentration at Time of Expiry: 87.2% I-123, 12.4% I-125, 0.4% Te-121
Metabolic model in MIRD Dose Estimate Report 5 followed for I-123 and I-125
Metabolic model in ICRP 30 followed for Te-121
^†Bladder voiding interval 4.8 hours.
Bladder ^†	5	1.7 (0.17)	1.7 (0.17)	2.9 (0.29)
	15	1.6 (0.16)	1.6 (0.16)	2.7 (0.27)
	25	1.4 (0.14)	1.5 (0.15)	2.4 (0.24)
Stomach Wall	5	0.96 (0.096)	0.98 (0.098)	1.7 (0.17)
	15	0.89 (0.089)	0.91 (0.091)	1.5 (0.15)
	25	0.82 (0.082)	0.85 (0.085)	1.4 (0.14)
Small Intestine	5	0.70 (0.070)	0.71 (0.071)	1.2 (0.12)
	15	0.65 (0.065)	0.67 (0.067)	1.1 (0.11)
	25	0.60 (0.060)	0.62 (0.062)	0.99 (0.099)
Liver	5	0.089 (0.0089)	0.13 (0.013)	0.16 (0.016)
	15	0.10 (0.010)	0.18 (0.018)	0.28 (0.028)
	25	0.11 (0.011)	0.24 (0.024)	0.41 (0.041)
Ovaries	5	0.18 (0.018)	0.19 (0.019)	0.18 (0.018)
	15	0.17 (0.017)	0.18 (0.018)	0.18 (0.018)
	25	0.16 (0.016)	0.18 (0.018)	0.17 (0.017)
Skeleton	5	0.11 (0.011)	0.16 (0.016)	0.12 (0.012)
	15	0.12 (0.012)	0.18 (0.018)	0.18 (0.018)
	25	0.14 (0.014)	0.21 (0.021)	0.24 (0.024)
Red Marrow	5	0.12 (0.012)	0.16 (0.016)	0.15 (0.015)
	15	0.12 (0.012)	0.18 (0.018)	0.21 (0.021)
	25	0.13 (0.013)	0.19 (0.019)	0.27 (0.027)
Testes	5	0.076 (0.0076)	0.089 (0.0089)	0.12 (0.012)
	15	0.072 (0.0072)	0.087 (0.0087)	0.12 (0.012)
	25	0.068 (0.0068)	0.085 (0.0085)	0.12 (0.012)
Thyroid	5	25 (2.5)	75 (7.5)	260 (26)
	15	77 (7.7)	230 (23)	780 (78)
	25	130 (13)	410 (41)	1300 (130)
Total Body	5	0.11 (0.011)	0.16 (0.016)	0.24 (0.024)
	15	0.14 (0.014)	0.25 (0.025)	0.47 (0.047)
	25	0.17 (0.017)	0.35 (0.035)	0.70 (0.070)

Contraindications

To date there are no known contraindications to the use of Sodium Iodide I 123 Capsules.

Pregnancy and lactation

Pregnancy

Pregnancy Category C Animal reproduction studies have not been conducted with this drug. It is also not known whether sodium iodide I-123 can cause fetal harm when administered to a pregnant woman or can affect reproductive capacity. Sodium iodide I-123 should be given to a pregnant woman only if clearly needed. Ideally, examinations using radiopharmaceuticals, especially those elective in nature, in women of child-bearing capability should be performed during the first few (approximately ten) days following the onset of menses.

Lactation

Nursing Mothers Since I-123 is excreted in human milk, formula-feeding should be substituted for breast-feeding if the agent must be administered to the mother during lactation.

For breastfeeding, also see LactMed (National Library of Medicine), which summarizes milk levels and infant effects.

Supply and cost

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Not the price at the counter

These are not what a patient pays at the pharmacy counter. They are what pharmacies, health plans, and government buyers pay, before manufacturer rebates. A patient's cost depends on their insurance (copay, coinsurance, or deductible) or the pharmacy's cash price.

VA Federal Supply ScheduleCMS NADACMedicare Part D plan filesMedicaid State Drug Utilization Data