Aminoglycoside extended-interval dosing

ClinDose template

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ClinDose template, review and adapt before use

Extended-interval dosing for eligible adults. Dose, dosing weight, and interval nomogram are set by your institution.

Weight-based dosing

Dose per kg set by your institution, interval by the level-based nomogram, using adjusted body weight (factor 0.4).

Set the mg/kg dose, when to use adjusted body weight, and rounding.

Monitoring

  • Random levelTiming after the first dose set by your nomogramTarget Interval per your institution's nomogramPlaceholder
  • Serum creatinineFrequency set by your institutionPlaceholder

Restriction criteria

  • ApprovalNot required
  • Exclusions set by your institution (for example pregnancy, burns, ascites, dialysis, endocarditis)

Protocol document

Label reference

  • The FDA label's traditional dosing for serious infections with normal kidney function: "3 mg/kg/day, administered in three equal doses every eight hours". Extended-interval dosing is not described in the label. (cited)

Sources