IV-to-PO conversion
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Pharmacists may convert eligible IV orders to the oral route when every criterion is met.
IV-to-PO conversion
- Tolerating oral intake or enteral feeds
- Functioning GI tract: no ileus, malabsorption, or uncontrolled vomiting or diarrhea
- Clinically improving and hemodynamically stable per your institution's definition
- Not treated for an infection that requires IV therapy (for example endocarditis, meningitis, or osteomyelitis) unless the prescriber approves
- No drug interaction with enteral feeds or chelating agents that can't be separated
| IV | Oral | Conversion |
|---|---|---|
| levofloxacin | levofloxacin | Set by your institutionRatio for your institution to confirm |
| linezolid | linezolid | Set by your institutionRatio for your institution to confirm |
| fluconazole | fluconazole | Set by your institutionRatio for your institution to confirm |
| metronidazole | metronidazole | Set by your institutionRatio for your institution to confirm |
| azithromycin | azithromycin | Set by your institutionRatio for your institution to confirm |
| doxycycline | doxycycline | Set by your institutionRatio for your institution to confirm |
| isavuconazonium | isavuconazonium | Same doseLabel: switching between the intravenous and oral formulations is acceptable as bioequivalence has been demonstrated; no loading dose when switching. |
| pantoprazole | pantoprazole | Set by your institutionRatio for your institution to confirm |
| famotidine | famotidine | Set by your institutionRatio for your institution to confirm |
| levetiracetam | levetiracetam | Set by your institutionRatio for your institution to confirm |
Sources
- FDA label for isavuconazonium (DailyMed), dosage in renal impairment, effective 2025-04-25