Vancomycin AUC-guided dosing

ClinDose template

Use as a template

Sign in and create or join an organization to copy this protocol into it as a draft.

ClinDose template, review and adapt before use

Pharmacy-to-dose for inpatients. Dose by weight, then adjust to your institution's AUC target using two levels or Bayesian software.

Weight-based dosing

Dose per kg set by your institution, interval by kidney function, then adjusted to levels, using actual body weight.

Set the loading dose, maintenance dose per kg, maximum single dose, and rounding increment your institution uses.

Monitoring

  • AUC24Estimate from two levels or Bayesian software once at steady stateTarget AUC 400–600 mg·h/L (confirm against your institution's guideline)Placeholder
  • Serum creatinineFrequency set by your institutionPlaceholder

Protocol document

Label reference

  • The FDA label's usual adult dose for normal kidney function: "The usual daily intravenous dose is 2 grams divided either as 500 mg every 6 hours or 1 gram every 12 hours." (cited)
  • AUC-guided dosing is not described in the FDA label. Your institution sets the targets.

Procedure

  • Confirm the indication, weight, and kidney function.
  • Order levels per this protocol and document the AUC estimate.

Sources