Ammonia n-13

FDA label, THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH, intravenous, effective 2019-10-30. Full label on DailyMed

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Quoted from the FDA label. Product labels differ by manufacturer and change over time; confirm against the label for the product you are using.

Radioactive Diagnostic Agent

Dosing in kidney impairment

Patient Preparation To increase renal clearance of radioactivity and to minimize radiation dose to the bladder, ensure that the patient is well hydrated before the procedure and encourage voiding as soon as a study is completed and as often as possible thereafter for at least one hour.

Table 1. N 13 Absorbed Radiation Dose Per Unit Activity (rem/mCi) for Adults and Pediatric Groups
Organ	Adult	15 - year old	10 - year old	5 - year old	1 - year old
Adrenals	0.0085	0.0096	0.016	0.025	0.048
Bladder wall	0.030	0.037	0.056	0.089	0.17
Bone surfaces	0.0059	0.0070	0.011	0.019	0.037
Brain	0.016	0.016	0.017	0.019	0.027
Breast	0.0067	0.0067	0.010	0.017	0.033
Stomach wall	0.0063	0.0078	0.012	0.019	0.037
Small intestine	0.0067	0.0081	0.013	0.021	0.041
*ULI	0.0067	0.0078	0.013	0.021	0.037
**LLI	0.0070	0.0078	0.013	0.020	0.037
Heart	0.0078	0.0096	0.015	0.023	0.041
Kidneys	0.017	0.021	0.031	0.048	0.089
Liver	0.015	0.018	0.029	0.044	0.085
Lungs	0.0093	0.011	0.018	0.029	0.056
Ovaries	0.0063	0.0085	0.014	0.021	0.041
Pancreas	0.0070	0.0085	0.014	0.021	0.041
Red marrow	0.0063	0.0078	0.012	0.020	0.037
Spleen	0.0093	0.011	0.019	0.030	0.056
Testes	0.0067	0.0070	0.011	0.018	0.035
Thyroid	0.0063	0.0081	0.013	0.021	0.041
Uterus	0.0070	0.0089	0.014	0.023	0.041
Other tissues	0.0059	0.0070	0.011	0.018	0.035

Table 1. N 13 Absorbed Radiation Dose Per Unit Activity (rem/mCi) for Adults and Pediatric Groups
Organ	Adult	15 - year old	10 - year old	5 - year old	1 - year old
Adrenals	0.0085	0.0096	0.016	0.025	0.048
Bladder wall	0.030	0.037	0.056	0.089	0.17
Bone surfaces	0.0059	0.0070	0.011	0.019	0.037
Brain	0.016	0.016	0.017	0.019	0.027
Breast	0.0067	0.0067	0.010	0.017	0.033
Stomach wall	0.0063	0.0078	0.012	0.019	0.037
Small intestine	0.0067	0.0081	0.013	0.021	0.041
*ULI	0.0067	0.0078	0.013	0.021	0.037
**LLI	0.0070	0.0078	0.013	0.020	0.037
Heart	0.0078	0.0096	0.015	0.023	0.041
Kidneys	0.017	0.021	0.031	0.048	0.089
Liver	0.015	0.018	0.029	0.044	0.085
Lungs	0.0093	0.011	0.018	0.029	0.056
Ovaries	0.0063	0.0085	0.014	0.021	0.041
Pancreas	0.0070	0.0085	0.014	0.021	0.041
Red marrow	0.0063	0.0078	0.012	0.020	0.037
Spleen	0.0093	0.011	0.019	0.030	0.056
Testes	0.0067	0.0070	0.011	0.018	0.035
Thyroid	0.0063	0.0081	0.013	0.021	0.041
Uterus	0.0070	0.0089	0.014	0.023	0.041
Other tissues	0.0059	0.0070	0.011	0.018	0.035

Preparation and administration

Prepare this dose

Your numbers for ammonia n-13. Take vial strength, diluent, and limits from the label below.

Dose

Basis

Vial or stock concentrationmg/mLAmount per vialmgFinal bag volumemLInfuse overminDrip set

Enter a dose to see draw volume, final concentration, and rates.

Inspect Ammonia N 13 Injection visually for particulate matter and discoloration before administration, whenever solution and container permit. Inspect Ammonia N 13 Injection visually for particulate matter and discoloration before administration, whenever solution and container permit.

Drug interactions

Check ammonia n-13 against a medication list

Label text (1 paragraph)

The possibility of interactions of Ammonia N 13 Injection with other drugs taken by patients undergoing PET imaging has not been studied.

Contraindications

None None

Safety data

Reported adverse events (FAERS)

Source: FDA Adverse Event Reporting System via openFDA

Liver injury (LiverTox)

LiverTox has no chapter for ammonia n-13. Check the label's hepatic warnings.

Source: LiverTox, NIDDK

Pregnancy and lactation

Breastfeeding (LactMed)

Information in this record refers to the use of ammonia N 13 as a diagnostic agent in PET scans. No information is available on the use of ammonia N 13 during breastfeeding. The Society for Nuclear Medicine and the International Commission on Radiological Protection states that breastfeeding need not be interrupted after administration of ammonia N 13,- although the manufacturer recommends withholding breastfeeding for 2 hours. This length of time is greater than 10 half-lives of the radioisotope, so the nursing infant should not be exposed to radiation if this the 2-hour time period is used. The mother can nurse just before administration of the radiopharmaceutical. If the mother has expressed and saved milk prior to the examination, she can feed it to the infant during the period of nursing interruption.

Source: LactMed: Ammonia N 13 (NICHD, public domain)Revised Oct 15, 2023

Supply and cost

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Products and NDCs

Recruiting clinical trials

Source: ClinicalTrials.gov API (NLM)Search on ClinicalTrials.gov