Fluciclovine f-18
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From MedlinePlus, U.S. National Library of Medicine
Radioactive Diagnostic Agent
Dosing in kidney impairment
| Organ/Tissue | Mean Absorbed Dose per Unit Administered Activity (microGy/MBq) |
| Adrenal glands | 16 |
| Brain | 9 |
| Breasts | 14 |
| Gallbladder wall | 17 |
| Lower large intestine wall | 12 |
| Small intestine wall | 13 |
| Stomach wall | 14 |
| Upper large intestine wall | 13 |
| Heart wall | 52 |
| Kidneys | 14 |
| Liver | 33 |
| Lungs | 34 |
| Muscle | 11 |
| Ovaries | 13 |
| Pancreas | 102 |
| Red bone marrow | 25 |
| Osteogenic cells | 23 |
| Skin | 8 |
| Spleen | 24 |
| Testes | 17 |
| Thymus gland | 12 |
| Thyroid | 10 |
| Urinary bladder wall | 25 |
| Uterus | 45 |
| Total body | 13 |
| Effective dose | 22 (microSv/MBq) |
Preparation and administration
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Recommended Dose and Administration Instructions The recommended dose is 370 MBq (10 mCi) administered as an intravenous bolus injection. Inspect Axumin visually for particulate matter and discoloration before administration. Do not use the drug if the solution contains particulate matter or is discolored. Use aseptic technique and radiation shielding when withdrawing and administering Axumin.
Calculate the necessary volume to administer based on calibration time and date, using a suitably calibrated instrument. The recommended maximum volume of injection of undiluted Axumin is 5mL. Axumin may be diluted with 0.9% Sodium Chloride Injection, USP. After the Axumin injection, administer an intravenous flush of sterile 0.9% Sodium Chloride Injection, USP to ensure full delivery of the dose.
Dispose of any unused drug in a safe manner in compliance with applicable regulations.
Patient Preparation Prior to PET Imaging Advise the patient to avoid any significant exercise for at least one day prior to PET imaging. Advise patients not to eat or drink for at least 4 hours (other than sips of water for taking medications) prior to administration of Axumin. Advise patients to void approximately 30 minutes to 60 minutes prior to administration of Axumin and then refrain from voiding until after the scan has been completed
Contraindications
None None ( 4 )
Safety data
Reported adverse events (FAERS)
Liver injury (LiverTox)
LiverTox has no chapter for fluciclovine f-18. Check the label's hepatic warnings.
Pregnancy and lactation
Pregnancy
8.1 Pregnancy Risk Summary Axumin is not indicated for use in females and there is no information on the risk of adverse development outcomes in pregnant women or animals with the use of fluciclovine F 18.
For breastfeeding, also see LactMed (National Library of Medicine), which summarizes milk levels and infant effects.
Supply and cost
Drug shortage status
Recalls (last 24 months)
Therapeutic equivalence (Orange Book)
Price ladder
Not the price at the counterThese are not what a patient pays at the pharmacy counter. They are what pharmacies, health plans, and government buyers pay, before manufacturer rebates. A patient's cost depends on their insurance (copay, coinsurance, or deductible) or the pharmacy's cash price.