Methenamine mandelate
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From MedlinePlus, U.S. National Library of Medicine
Dosing in kidney impairment
CONTRAINDICATIONS Contraindicated in renal insufficiency. Methenamine mandelate, USP should not be used in patients who have previously exhibited hypersensitivity to it.
Drug interactions
Check methenamine mandelate against a medication listLabel text (1 paragraph)
Formaldehyde and sulfamethizole form an insoluble precipitate in acid urine; therefore, methenamine mandelate, USP should not be administered concurrently with sulfamethizole.
Contraindications
Contraindicated in renal insufficiency. Methenamine mandelate, USP should not be used in patients who have previously exhibited hypersensitivity to it.
Safety data
Reported adverse events (FAERS)
Liver injury (LiverTox)
LiverTox has no chapter for methenamine mandelate. Check the label's hepatic warnings.
Pregnancy and lactation
Pregnancy
Pregnancy Category C: Animal reproduction studies have not been conducted with methenamine mandelate, USP. It is also not known whether methenamine mandelate, USP can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Methenamine mandelate, USP should be given to a pregnant woman only if clearly needed. Since introduction, published reports on the use of methenamine mandelate, USP in pregnant women have not shown an increased risk of fetal abnormalities from use during pregnancy.
Breastfeeding (LactMed)
Both methenamine and mandelic acid pass into milk in small quantities. Methenamine mandelate appears acceptable to use, even while nursing a newborn.
Supply and cost
Drug shortage status
Recalls (last 24 months)
Therapeutic equivalence (Orange Book)
Price ladder
Not the price at the counterThese are not what a patient pays at the pharmacy counter. They are what pharmacies, health plans, and government buyers pay, before manufacturer rebates. A patient's cost depends on their insurance (copay, coinsurance, or deductible) or the pharmacy's cash price.