Coding and coverage · ICD-10-CM

D21 Other benign neoplasms of connective and other soft tissue

Not billable (header)Chapter 2

Report one of the more specific codes below.

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Codes under this one

  • D21.0 Benign neoplasm of connective and other soft tissue of head, face and neck
  • D21.1 Benign neoplasm of connective and other soft tissue of upper limb, including shoulderHeader
  • D21.2 Benign neoplasm of connective and other soft tissue of lower limb, including hipHeader
  • D21.3 Benign neoplasm of connective and other soft tissue of thorax
  • D21.4 Benign neoplasm of connective and other soft tissue of abdomen
  • D21.5 Benign neoplasm of connective and other soft tissue of pelvis
  • D21.6 Benign neoplasm of connective and other soft tissue of trunk, unspecified
  • D21.9 Benign neoplasm of connective and other soft tissue, unspecified

Instructional notes

Chapter 2

Notes
  • Functional activity
  • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
  • Morphology [Histology]
  • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
  • Primary malignant neoplasms overlapping site boundaries
  • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
  • Malignant neoplasm of ectopic tissue
  • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).

This code

Excludes1Not coded here: never report with this code, except when the two conditions are unrelated.
  • benign neoplasm of articular cartilage (D16.-)
  • benign neoplasm of cartilage of larynx (D14.1)
  • benign neoplasm of cartilage of nose (D14.0)
  • benign neoplasm of connective tissue of breast (D24.-)
  • benign neoplasm of peripheral nerves and autonomic nervous system (D36.1-)
  • benign neoplasm of peritoneum (D20.1)
  • benign neoplasm of retroperitoneum (D20.0)
  • benign neoplasm of uterine ligament, any (D28.2)
  • benign neoplasm of vascular tissue (D18.-)
  • hemangioma (D18.0-)
  • lipomatous neoplasm (D17.-)
  • lymphangioma (D18.1)
  • uterine leiomyoma (D25.-)
Includes
  • benign neoplasm of blood vessel
  • benign neoplasm of bursa
  • benign neoplasm of cartilage
  • benign neoplasm of fascia
  • benign neoplasm of fat
  • benign neoplasm of ligament, except uterine
  • benign neoplasm of lymphatic channel
  • benign neoplasm of muscle
  • benign neoplasm of synovia
  • benign neoplasm of tendon (sheath)
  • benign stromal tumors

Chapter 2: Neoplasms · D10-D36 Benign neoplasms, except benign neuroendocrine tumors (D10-D36)

Source: ICD-10-CM FY 2027 code descriptions and tabular list (CMS and CDC National Center for Health Statistics), effective 2026-10-01 through 2027-09-30 · CMS ICD-10 files. HCC mapping: CMS-HCC V28, payment year 2027. As of 2026-11-04.

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