Coding and coverage · ICD-10-CM

T80

T80.5 Anaphylactic reaction due to serum

Not billable (header)Chapter 19

This code needs a 7th character (use X as a placeholder for missing characters).

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Codes under this one

  • T80.51 Anaphylactic reaction due to administration of blood and blood productsHeader
  • T80.52 Anaphylactic reaction due to vaccinationHeader
  • T80.59 Anaphylactic reaction due to other serumHeader

Instructional notes

Chapter 19

Excludes2Not included here: the patient may have both; report both when both are present.
Use additional codeAdd a second code for the full picture.
  • code to identify any retained foreign body, if applicable (Z18.-)
Notes
  • Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
  • The chapter uses the S-section for coding different types of injuries related to single body regions and the T-section to cover injuries to unspecified body regions as well as poisoning and certain other consequences of external causes.

T80

Excludes2Not included here: the patient may have both; report both when both are present.
  • bone marrow transplant rejection (T86.01)
  • febrile nonhemolytic transfusion reaction (R50.84)
  • fluid overload due to transfusion (E87.71)
  • posttransfusion purpura (D69.51)
  • transfusion associated circulatory overload (TACO) (E87.71)
  • transfusion (red blood cell) associated hemochromatosis (E83.111)
  • transfusion related acute lung injury (TRALI) (J95.84)
Includes
  • complications following perfusion
7th charactersThe appropriate 7th character is to be added to each code from category T80
  • A initial encounter
  • D subsequent encounter
  • S sequela

This code

Excludes1Not coded here: never report with this code, except when the two conditions are unrelated.
  • ABO incompatibility reaction due to transfusion of blood or blood products (T80.3-)
  • allergic reaction or shock NOS (T78.2)
  • anaphylactic reaction or shock NOS (T78.2)
  • anaphylactic reaction or shock due to adverse effect of correct medicinal substance properly administered (T88.6)
  • other serum reaction (T80.6-)
Inclusion terms
  • Allergic shock due to serum
  • Anaphylactic shock due to serum
  • Anaphylactoid reaction due to serum
  • Anaphylaxis due to serum

Chapter 19: Injury, poisoning and certain other consequences of external causes · T07-T88 Injury, poisoning and certain other consequences of external causes (T07-T88)

Source: ICD-10-CM FY 2027 code descriptions and tabular list (CMS and CDC National Center for Health Statistics), effective 2026-10-01 through 2027-09-30 · CMS ICD-10 files. HCC mapping: CMS-HCC V28, payment year 2027. As of 2026-11-04.

Coverage and payment depend on the claim details; confirm with the Medicare Administrative Contractor.