Coding and coverage · ICD-10-CM

D89 › D89.8 › D89.81

D89.812 Acute on chronic graft-versus-host disease

BillableCMS-HCC V28: HCC 454Chapter 3
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Instructional notes

Chapter 3

Excludes2Not included here: the patient may have both; report both when both are present.
  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Section D80-D89

Excludes1Not coded here: never report with this code, except when the two conditions are unrelated.
  • autoimmune disease (systemic) NOS (M35.9)
  • functional disorders of polymorphonuclear neutrophils (D71-)
Excludes2Not included here: the patient may have both; report both when both are present.
  • human immunodeficiency virus [HIV] disease (B20)
Includes
  • defects in the complement system
  • immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
  • sarcoidosis

D89

Excludes1Not coded here: never report with this code, except when the two conditions are unrelated.
  • hyperglobulinemia NOS (R77.1)
  • monoclonal gammopathy (of undetermined significance) (D47.2)
Excludes2Not included here: the patient may have both; report both when both are present.
  • transplant failure and rejection (T86.-)

D89.81

Code firstSequence the underlying condition first.
  • underlying cause, such as:
  • complications of transplanted organs and tissue (T86.-)
  • complications of blood transfusion (T80.89)
Use additional codeAdd a second code for the full picture.
  • code to identify associated manifestations, such as:
  • desquamative dermatitis (L30.8)
  • diarrhea (R19.7)
  • elevated bilirubin (R17)
  • hair loss (L65.9)

Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism · D80-D89 Certain disorders involving the immune mechanism (D80-D89)

Source: ICD-10-CM FY 2027 code descriptions and tabular list (CMS and CDC National Center for Health Statistics), effective 2026-10-01 through 2027-09-30 · CMS ICD-10 files. HCC mapping: CMS-HCC V28, payment year 2027. As of 2026-11-04.

Coverage and payment depend on the claim details; confirm with the Medicare Administrative Contractor.