Coding and coverage · ICD-10-CM

Z16 › Z16.3

Z16.34 Resistance to antimycobacterial drug(s)

Not billable (header)Chapter 21

Report one of the more specific codes below.

Codes under this one

  • Z16.341 Resistance to single antimycobacterial drug
  • Z16.342 Resistance to multiple antimycobacterial drugs

Instructional notes

Chapter 21

Notes
  • Z codes represent reasons for encounters. A corresponding procedure code must accompany a Z code if a procedure is performed. Categories Z00-Z99 are provided for occasions when circumstances other than a disease, injury or external cause classifiable to categories A00-Y89 are recorded as 'diagnoses' or 'problems'. This can arise in two main ways:
  • (a) When a person who may or may not be sick encounters the health services for some specific purpose, such as to receive limited care or service for a current condition, to donate an organ or tissue, to receive prophylactic vaccination (immunization), or to discuss a problem which is in itself not a disease or injury.
  • (b) When some circumstance or problem is present which influences the person's health status but is not in itself a current illness or injury.

Z16

Excludes1Not coded here: never report with this code, except when the two conditions are unrelated.
  • Methicillin resistant Staphylococcus aureus infection (A49.02)
  • Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
  • Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)
Code firstSequence the underlying condition first.
  • the infection
Notes
  • The codes in this category are provided for use as additional codes to identify the resistance and non-responsiveness of a condition to antimicrobial drugs.

Z16.3

Excludes1Not coded here: never report with this code, except when the two conditions are unrelated.

This code

Inclusion terms
  • Resistance to tuberculostatics

Chapter 21: Factors influencing health status and contact with health services · Z16 Resistance to antimicrobial drugs (Z16)

Source: ICD-10-CM FY 2027 code descriptions and tabular list (CMS and CDC National Center for Health Statistics), effective 2026-10-01 through 2027-09-30 · CMS ICD-10 files. HCC mapping: CMS-HCC V28, payment year 2027. As of 2026-11-04.

Coverage and payment depend on the claim details; confirm with the Medicare Administrative Contractor.