Coding and coverage · ICD-10-CM

D81 › D81.8

D81.82 Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]

BillableCMS-HCC V28: HCC 114Chapter 3
Check coverage with this diagnosis

Instructional notes

Chapter 3

Excludes2Not included here: the patient may have both; report both when both are present.
  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Section D80-D89

Excludes1Not coded here: never report with this code, except when the two conditions are unrelated.
  • autoimmune disease (systemic) NOS (M35.9)
  • functional disorders of polymorphonuclear neutrophils (D71-)
Excludes2Not included here: the patient may have both; report both when both are present.
  • human immunodeficiency virus [HIV] disease (B20)
Includes
  • defects in the complement system
  • immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
  • sarcoidosis

D81

Excludes1Not coded here: never report with this code, except when the two conditions are unrelated.
  • autosomal recessive agammaglobulinemia (Swiss type) (D80.0)

This code

Code also
  • , if applicable, any associated manifestations, such as:
  • bronchiectasis (J47.-)
  • herpes virus infections (B00.-)
  • other acute respiratory tract infections (J00-J06; J20-J22)
  • other infections (A00-B99)
  • pneumonia (J12-J18)
Inclusion terms
  • p110d-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency [PASLI] disease

Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism · D80-D89 Certain disorders involving the immune mechanism (D80-D89)

Source: ICD-10-CM FY 2027 code descriptions and tabular list (CMS and CDC National Center for Health Statistics), effective 2026-10-01 through 2027-09-30 · CMS ICD-10 files. HCC mapping: CMS-HCC V28, payment year 2027. As of 2026-11-04.

Coverage and payment depend on the claim details; confirm with the Medicare Administrative Contractor.