Methadone 10 mg/mL oral solution
Ingredients
| Ingredient | Role | For 100 mL |
|---|---|---|
| Methadone hydrochloride | active | 1 g |
| Methylparaben and propylparaben (optional) | preservative | See the study |
| Aqueous vehicle (see the study) | vehicle | q.s. to 100 mL |
- Strength
- 10 mg/mL
- Starting material
- Methadone hydrochloride bulk powder
- Container
- Amber glass bottles (closed and in daily use)
- Formulations with and without parabens performed the same.
Amounts are ClinDose's arithmetic from the study's concentration; follow the study for the method.
Storage and beyond-use date
| Storage | BUD | Basis |
|---|---|---|
| Refrigerated | 91 days | Cited stability study. Duration supported by the cited stability study for this formula, container, and storage. |
| Room temperature | 91 days | Cited stability study. Duration supported by the cited stability study for this formula, container, and storage. |
Only the storage conditions the source covers are listed. Use the BUD assistant for other cases. The BUD may not be later than any component's expiration date. Verify against the current official USP chapter.
Ingredient checks
No FDA compounding list or NIOSH flags for the active ingredient.
Source
Álvaro-Alonso EA, Lorenzo MP, Gonzalez-Prieto A, Izquierdo-García E, Escobar-Rodríguez I, Aguilar-Ros A. Physicochemical and Microbiological Stability of Two Oral Solutions of Methadone Hydrochloride 10 mg/mL. Molecules. 2022;27(9):2812. PMID 35566167. PMC9105510. License: CC BY (checked 2026-11-06). Read the article · DOI
For licensed clinicians. Use with clinical judgment.