Vancomycin 12.5 mg/mL oral solution
Ingredients
| Ingredient | Role | For 100 mL |
|---|---|---|
| Vancomycin hydrochloride | active | 1.25 g |
| Citric acid (with bulk powder) | buffer | See the study |
| Simple Syrup, USP | vehicle | q.s. to 100 mL |
- Strength
- 12.5 mg/mL
- Starting material
- Vancomycin hydrochloride injectable powder, or bulk powder buffered with citric acid
- Container
- High-density polyethylene (HDPE) bottles
- Buffering with citric acid kept pH in range; the unbuffered formulation drifted.
Amounts are ClinDose's arithmetic from the study's concentration; follow the study for the method.
Storage and beyond-use date
| Storage | BUD | Basis |
|---|---|---|
| Refrigerated | 90 days | Cited stability study. Duration supported by the cited stability study for this formula, container, and storage. |
| Room temperature | 30 days | Cited stability study. Duration supported by the cited stability study for this formula, container, and storage. |
Only the storage conditions the source covers are listed. Use the BUD assistant for other cases. The BUD may not be later than any component's expiration date. Verify against the current official USP chapter.
Ingredient checks
No FDA compounding list or NIOSH flags for the active ingredient.
Source
Arroyo-Solorzano JD, Martínez-Carpio S, Blanco-Barrantes J, et al.. Analysis of the Stability of Compounded Vancomycin Hydrochloride Oral Solution: A Comparison Between Formulations Prepared Using a Commercial Product and Using the Pure Active Ingredient. Cureus. 2025;17(9):e91993. PMID 41084695. PMC12515258. License: CC BY (checked 2026-11-06). Read the article · DOI
For licensed clinicians. Use with clinical judgment.