Evolocumab
- Biologic
- Repatha
Therapy management checklist
Screening, baseline and ongoing monitoring with the label's stated frequency, hold and discontinue criteria, and counseling points, each quoted from the FDA label.
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Storage and cold chain
Evolocumab: storage and handling
- Refrigerate
- Yes, as the label states
Label statement
Store refrigerated at 2°C to 8°C (36°F to 46°F) in the original carton to protect from light.
- Freezing
- Do not freeze
Label statement
Do not freeze.
- Room temperature
- up to 30 days at or below 25°C (77°F)
Label statement
For convenience, REPATHA may be kept at room temperature at 68°F to 77°F (20°C to 25°C) in the original carton for 30 days.
- Room temperature
- up to 30 days at or below 25°C (77°F)
Label statement
If removed from the refrigerator, the prefilled syringe should be kept at room temperature at 68°F to 77°F (20°C to 25°C) in the original carton and must be used within 30 days.
- Room temperature
- up to 30 days
Label statement
Place the prefilled syringe in a sharps disposal container if it has reached room temperature and has not been used within 30 days.
- Room temperature
- up to 30 days at or below 25°C (77°F)
Label statement
If needed, REPATHA can be stored at room temperature between 68°F to 77°F (20°C to 25°C) in the original carton for up to 30 days.
- Room temperature
- up to 30 days
Label statement
Throw away REPATHA that has been stored at room temperature for more than 30 days.
- Back into the refrigerator
- Not addressed
- Light
- Protect from light
Label statement
Store refrigerated at 2°C to 8°C (36°F to 46°F) in the original carton to protect from light.
- Shaking
- Do not shake
Label statement
Do not shake.
All storage statements on the label (18)
- Store refrigerated at 2°C to 8°C (36°F to 46°F) in the original carton to protect from light.
- Do not freeze.
- Do not shake.
- For convenience, REPATHA may be kept at room temperature at 68°F to 77°F (20°C to 25°C) in the original carton for 30 days.
- If not used within the 30 days, discard REPATHA.
- Storage of REPATHA : Keep the prefilled syringe in the original carton to protect from light during storage.
- Keep the prefilled syringe in the refrigerator between 36°F to 46°F (2°C to 8°C).
- If removed from the refrigerator, the prefilled syringe should be kept at room temperature at 68°F to 77°F (20°C to 25°C) in the original carton and must be used within 30 days.
- Place the prefilled syringe in a sharps disposal container if it has reached room temperature and has not been used within 30 days.
- Do not freeze the prefilled syringe or use a prefilled syringe that has been frozen.
- Do not store the prefilled syringe in extreme heat or cold.
- Do not use the prefilled syringe after the expiration date.
- Store REPATHA in the refrigerator between 36°F to 46°F (2°C to 8°C).
- Store REPATHA in the original carton until use to protect it from light.
- If needed, REPATHA can be stored at room temperature between 68°F to 77°F (20°C to 25°C) in the original carton for up to 30 days.
- Throw away REPATHA that has been stored at room temperature for more than 30 days.
- Do not freeze REPATHA.
- Do not shake REPATHA.
FDA label version 41, effective November 20, 2024. DailyMed
Dosing and titration calendar
Built only from the schedules the label states (loading, titration, day schedules, cycles and weight bands). Steps the label states in words the calendar cannot place are shown, not guessed.
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Medicare Part D coverage
5,496 Part D plans, CMS formulary files 2026Q3. Look up tier, PA, step therapy and quantity limits by plan
Patient assistance
No manufacturer program page is listed for this drug yet.
Independent foundations and the full directory (checked 2026-11-06). Eligibility and amounts are set by each program; open its page for them.
For licensed clinicians. Use with clinical judgment. Statements are quoted from the FDA label; confirm against the label for the product you are using.