Insulin glulisine
- Biologic
- Apidra
Therapy management checklist
Screening, baseline and ongoing monitoring with the label's stated frequency, hold and discontinue criteria, and counseling points, each quoted from the FDA label.
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Storage and cold chain
Insulin glulisine: storage and handling
- Refrigerate
- Yes, as the label states
Label statement
Unopened vials can be used until the expiration date on the carton and label if they have been stored in the refrigerator.
- Freezing
- Do not freeze
Label statement
Do not freeze.
- Room temperature
- up to 2 days
Label statement
Intravenous Use Diluted APIDRA in infusion bags in normal saline solution (0.9% Sodium Chloride Injection, USP) are stable at room temperature for 48 hours [see Dosage and Administration (2.2) ] .
- Room temperature
- up to 28 days
Label statement
Unopened vials should be thrown away after 28 days if they are stored at room temperature.
- Room temperature
- up to 28 days at or below 25°C (77°F)
Label statement
After APIDRA vials have been opened (in-use) Store in-use (opened) APIDRA vials in a refrigerator from 36°F to 46°F (2°C to 8°C) or at room temperature below 77°F (25°C) for up to 28 days.
- Back into the refrigerator
- Not addressed
- Light
- Not addressed
- Shaking
- Not addressed
All storage statements on the label (15)
- Do not freeze.
- Do not use after the expiration date (see carton and container).
- Storage conditions are summarized in the following table: Not in-use (unopened) Refrigerated (36°F-46°F [2°C-8°C]).
- Intravenous Use Diluted APIDRA in infusion bags in normal saline solution (0.9% Sodium Chloride Injection, USP) are stable at room temperature for 48 hours [see Dosage and Administration (2.2) ] .
- Unopened (not in-use) APIDRA vials Store unused APIDRA vials in the refrigerator from 36°F to 46°F (2°C to 8°C).
- Do not freeze APIDRA.
- Keep APIDRA away from direct heat and light.
- If a vial has been frozen or overheated, throw it away.
- Unopened vials can be used until the expiration date on the carton and label if they have been stored in the refrigerator.
- Unopened vials should be thrown away after 28 days if they are stored at room temperature.
- After APIDRA vials have been opened (in-use) Store in-use (opened) APIDRA vials in a refrigerator from 36°F to 46°F (2°C to 8°C) or at room temperature below 77°F (25°C) for up to 28 days.
- Keep APIDRA out of direct heat and light.
- If a vial has been frozen, throw it away.
- APIDRA in an insulin pump Throw away APIDRA in the pump reservoir if it has been exposed to temperatures higher than 98.6°F (37°C).
- This may occur if the pump housing, cover, tubing, or sport case is exposed to sunlight or direct heat.
FDA label version 28, effective November 25, 2025. DailyMed
Dosing and titration calendar
Built only from the schedules the label states (loading, titration, day schedules, cycles and weight bands). Steps the label states in words the calendar cannot place are shown, not guessed.
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Medicare Part D coverage
5,496 Part D plans, CMS formulary files 2026Q3. Look up tier, PA, step therapy and quantity limits by plan
Patient assistance
No manufacturer program page is listed for this drug yet.
Independent foundations and the full directory (checked 2026-11-06). Eligibility and amounts are set by each program; open its page for them.
For licensed clinicians. Use with clinical judgment. Statements are quoted from the FDA label; confirm against the label for the product you are using.