Insulin lispro protamine and insulin lispro
- Biologic
- Humalog Mix75/25
Therapy management checklist
Screening, baseline and ongoing monitoring with the label's stated frequency, hold and discontinue criteria, and counseling points, each quoted from the FDA label.
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Storage and cold chain
Insulin lispro protamine and insulin lispro: storage and handling
- Refrigerate
- Yes, as the label states
Label statement
All unopened vials: Store all unopened vials in the refrigerator at 36°F to 46°F (2°C to 8°C).
- Freezing
- Do not freeze
Label statement
Do not freeze and do not use if it has been frozen.
- Room temperature
- up to 28 days
Label statement
See storage table below: a When stored at room temperature, HUMALOG Mix75/25 vial can only be used for a total of 28 days including both not in use (unopened) and in-use (opened) storage time. b When stored at room temperature, HUMALOG Mix75/25 KwikPen can only be used for a total of 10 days including both not in-use (unopened) and in-use (opened) storage time.
- Room temperature
- up to 28 days at or below 30°C (86°F)
Label statement
Not In-Use (Unopened) Refrigerated (36° to 46°F [2° to 8°C]) Not In-Use (Unopened) Room Temperature (up to 86°F [30°C]) In-Use (Opened) (see temperature below) 10 mL multiple-dose vial a Until expiration date 28 days 28 days Refrigerated or room temperature 3 mL single-patient-use KwikPen b prefilled pen Until expiration date 10 days 10 days Room temperature only (Do not refrigerate)
- Room temperature
- up to 28 days
Label statement
Unopened vials should be thrown away after 28 days, if they are stored at room temperature.
- Room temperature
- up to 28 days at or below 30°C (86°F)
Label statement
After vials have been opened: Store opened vials in the refrigerator or at room temperature up to 86°F (30°C) for up to 28 days.
- Back into the refrigerator
- Not addressed
- Light
- Not addressed
- Shaking
- Not addressed
All storage statements on the label (12)
- Protect from direct heat and light.
- Do not freeze and do not use if it has been frozen.
- See storage table below: a When stored at room temperature, HUMALOG Mix75/25 vial can only be used for a total of 28 days including both not in use (unopened) and in-use (opened) storage time. b When stored at room temperature, HUMALOG Mix75/25 KwikPen can only be used for a total of 10 days including both not in-use (unopened) and in-use (opened) storage time.
- Not In-Use (Unopened) Refrigerated (36° to 46°F [2° to 8°C]) Not In-Use (Unopened) Room Temperature (up to 86°F [30°C]) In-Use (Opened) (see temperature below) 10 mL multiple-dose vial a Until expiration date 28 days 28 days Refrigerated or room temperature 3 mL single-patient-use KwikPen b prefilled pen Until expiration date 10 days 10 days Room temperature only (Do not refrigerate)
- All unopened vials: Store all unopened vials in the refrigerator at 36°F to 46°F (2°C to 8°C).
- Do not freeze.
- Do not use if HUMALOG Mix75/25 has been frozen.
- Keep away from heat and out of direct light.
- Unopened vials can be used until the expiration date on the carton and label, if they have been stored in the refrigerator.
- Unopened vials should be thrown away after 28 days, if they are stored at room temperature.
- After vials have been opened: Store opened vials in the refrigerator or at room temperature up to 86°F (30°C) for up to 28 days.
- Keep vials away from heat and out of direct light.
FDA label version 54, effective June 16, 2026. DailyMed
Dosing and titration calendar
Built only from the schedules the label states (loading, titration, day schedules, cycles and weight bands). Steps the label states in words the calendar cannot place are shown, not guessed.
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Medicare Part D coverage
5,496 Part D plans, CMS formulary files 2026Q3. Look up tier, PA, step therapy and quantity limits by plan
Patient assistance
No manufacturer program page is listed for this drug yet.
Independent foundations and the full directory (checked 2026-11-06). Eligibility and amounts are set by each program; open its page for them.
For licensed clinicians. Use with clinical judgment. Statements are quoted from the FDA label; confirm against the label for the product you are using.