Interferon beta-1a

• Refrigerate AVONEX prefilled syringes and autoinjectors at 2°C to 8°C (36°F to 46°F) in the original carton to protect from light.
• DO NOT FREEZE.
• Once removed from the refrigerator, allow prefilled syringes and autoinjectors to warm to room temperature (about 30 minutes).
• Do not use external heat sources such as hot water to warm AVONEX.
• Should refrigeration be unavailable, a prefilled syringe or autoinjector may be stored at room temperature up to 25°C (77°F) for a period up to 7 days.
• Once the product is removed from the refrigerator, it must not be stored above 25°C (77°F).
• If the product has been exposed to conditions other than those recommended, DISCARD THE PRODUCT and DO NOT USE .
• Do not use beyond the expiration date.
• Store AVONEX in the refrigerator between 36°F to 46°F (2°C to 8°C).
• Do not freeze AVONEX.
• Do not use AVONEX that has been frozen.
• If you cannot refrigerate your AVONEX PEN, you can store your AVONEX PEN at room temperature up to 77°F (25°C) for up to 7 days.
• Do not store AVONEX above 77°F (25°C).
• Do not use AVONEX that is stored at temperatures higher than 77°F (25°C).
• Throw AVONEX away in an FDA-cleared sharps disposal container if it has not been stored as stated above.
• (See After the AVONEX injection section at the end of this Instructions for Use.) Keep AVONEX in the original carton to protect it from light.
• Take 1 AVONEX PEN Administration Dose Pack out of the refrigerator about 30 minutes before you plan on injecting the AVONEX dose to allow it to reach room temperature.
• Do not use external heat sources such as hot water to warm the AVONEX PEN.
• Check the expiration date printed on the AVONEX PEN, AVONEX PEN Administration Dose Pack carton, and the outer carton.
• Do not use the AVONEX PEN past the expiration date.

FDA label version 23, effective November 19, 2025. DailyMed