Dexamethasone sodium phosphate injection
Other products: Dexamethasone
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From MedlinePlus, U.S. National Library of Medicine
Dosing in kidney impairment
Usage in Pregnancy Since adequate human reproduction studies have not been done with corticosteroids, use of these drugs in pregnancy or in women of childbearing potential requires that the anticipated benefits be weighed against the possible hazards to the mother and embryo or fetus. Infants born of mothers who have received substantial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism.
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Preparation and administration
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Solutions used for intravenous administration or further dilution of this product should be preservative-free when used in the neonate, especially the premature infant. When it is mixed with an infusion solution, sterile precautions should be observed. Since infusion solutions generally do not contain preservatives, mixtures should be used within 24 hours.
The frequency usually ranges from once every three to five days to once every two to three weeks. Frequent intra-articular injection may result in damage to joint tissues. Some of the usual single doses are: [See table below.] Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever the solution and container permit.
| Author* | Dosage |
| Cavanagh1 | 3 mg/kg of body weight per 24 hours by constant intravenous infusion after an initial |
| Dietzman2 | intravenous injection of 20 mg |
| Frank3 | 2 to 6 mg/kg of body weight as a single intravenous injection |
| Oaks4 | 40 mg initially followed by repeat intravenous injection every 4 to 6 hours while shock persists |
| Schumer5 | 1 mg/kg of body weight as a single intravenous injection |
Drug interactions
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- Dexamethasone sodium phosphate injection
Supplement interactions
Dietary supplement interactions
1 noted- Corticosteroid medications, such as prednisone (Deltasone, Rayos, and Sterapred), are often prescribed to reduce inflammation. These medications can reduce calcium absorption and impair vitamin D metabolism.
Contraindications
Systemic fungal infections. (See WARNINGS regarding amphotericin B)
Safety data
Reported adverse events (FAERS)
Liver injury (LiverTox)
LiverTox has no chapter for dexamethasone sodium phosphate injection. Check the label's hepatic warnings.
Pregnancy and lactation
Breastfeeding (LactMed)
Little information is available on the use of systemic dexamethasone during breastfeeding. Short-term use of dexamethasone is unlikely to affect the breastfed infant. An alternate corticosteroid might be preferred for long-tern use. Local injections, such as for tendinitis, are not expected to cause any adverse effects in breastfed infants. Medium to large doses of corticosteroids, including dexamethasone, given systemically or injected into joints or the breast have been reported to cause temporary reduction of lactation. See also Dexamethasone, Topical.
Supply and cost
Drug shortage status
Recalls (last 24 months)
Therapeutic equivalence (Orange Book)
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