Insulin lispro

  • Biologic
  • Humalog

Therapy management checklist

Screening, baseline and ongoing monitoring with the label's stated frequency, hold and discontinue criteria, and counseling points, each quoted from the FDA label.

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Storage and cold chain

Insulin lispro: storage and handling

Refrigerate
Yes, as the label states
Label statement
Storage of Diluted HUMALOG U-100 for Subcutaneous Injection — Diluted HUMALOG for subcutaneous injection may be stored for 28 days when refrigerated at 41°F (5°C) and for 14 days at room temperature up to 86°F (30°C) [see Dosage and Administration ( 2.2 )].
Freezing
Do not freeze
Label statement
Do not freeze and do not use if it has been frozen.
Room temperature
up to 28 days
Label statement
See table below for storage information: * When stored at room temperature, HUMALOG U-100 and U-200 can only be used for a total of 28 days, including both not in-use (unopened) and in-use (opened) storage time.
Room temperature
up to 28 days at or below 30°C (86°F)
Label statement
Storage of Diluted HUMALOG U-100 for Subcutaneous Injection — Diluted HUMALOG for subcutaneous injection may be stored for 28 days when refrigerated at 41°F (5°C) and for 14 days at room temperature up to 86°F (30°C) [see Dosage and Administration ( 2.2 )].
Room temperature
up to 2 days
Label statement
The prepared intravenous infusions bags may then be used at room temperature for up to an additional 48 hours [see Dosage and Administration ( 2.2 )] .
Room temperature
up to 28 days
Label statement
Unopened vials should be thrown away after 28 days, if they are stored at room temperature.
Room temperature
up to 28 days at or below 30°C (86°F)
Label statement
After vials have been opened: Store opened vials in the refrigerator or at room temperature up to 86°F (30°C) for up to 28 days.
Back into the refrigerator
Not addressed
Light
Not addressed
Shaking
Not addressed

Temperature excursion helper

Answers only from this label's storage statements. It does not judge whether a product is still usable beyond what the label states.

Within the label's stated room-temperature allowance (up to 28 days). Follow the label's instructions for what to do next.

Entered: 1 day at up to 77°F (25°C).

See table below for storage information: * When stored at room temperature, HUMALOG U-100 and U-200 can only be used for a total of 28 days, including both not in-use (unopened) and in-use (opened) storage time.
HUMALOG in an insulin pump: Throw away HUMALOG in the pump reservoir if it has been exposed to temperatures higher than 98.6°F (37°C).

If anything else happened to the product, or you are unsure, Contact the manufacturer at 1-800-545-5979 (the number printed on the label) about this product.

Where the label prints this number
If you have any questions or problems with your HUMALOG, contact Lilly at 1-800-Lilly-Rx (1-800-545-5979) or call your healthcare provider for help.
All storage statements on the label (15)
  • Protect from direct heat and light.
  • Do not freeze and do not use if it has been frozen.
  • See table below for storage information: * When stored at room temperature, HUMALOG U-100 and U-200 can only be used for a total of 28 days, including both not in-use (unopened) and in-use (opened) storage time.
  • Storage of Diluted HUMALOG U-100 for Subcutaneous Injection — Diluted HUMALOG for subcutaneous injection may be stored for 28 days when refrigerated at 41°F (5°C) and for 14 days at room temperature up to 86°F (30°C) [see Dosage and Administration ( 2.2 )].
  • Storage of Intravenous Infusion Preparations with HUMALOG U-100 Intravenous infusion bags prepared with HUMALOG U-100 may be stored for 48 hours when refrigerated at 36° to 46°F (2° to 8°C).
  • The prepared intravenous infusions bags may then be used at room temperature for up to an additional 48 hours [see Dosage and Administration ( 2.2 )] .
  • All unopened vials: Store all unopened vials in the refrigerator at 36°F to 46°F (2°C to 8°C).
  • Do not freeze.
  • Do not use if HUMALOG has been frozen.
  • Keep away from heat and out of direct light.
  • Unopened vials can be used until the expiration date on the carton and label, if they have been stored in the refrigerator.
  • Unopened vials should be thrown away after 28 days, if they are stored at room temperature.
  • After vials have been opened: Store opened vials in the refrigerator or at room temperature up to 86°F (30°C) for up to 28 days.
  • Keep vials away from heat and out of direct light.
  • HUMALOG in an insulin pump: Throw away HUMALOG in the pump reservoir if it has been exposed to temperatures higher than 98.6°F (37°C).

FDA label version 87, effective June 16, 2026. DailyMed

Dosing and titration calendar

Built only from the schedules the label states (loading, titration, day schedules, cycles and weight bands). Steps the label states in words the calendar cannot place are shown, not guessed.

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Medicare Part D coverage

73%of plans list it
20%of those: prior authorization
0%step therapy
14%quantity limit
0%specialty tier

5,496 Part D plans, CMS formulary files 2026Q3. Look up tier, PA, step therapy and quantity limits by plan

Patient assistance

No manufacturer program page is listed for this drug yet.

Independent foundations and the full directory (checked 2026-11-06). Eligibility and amounts are set by each program; open its page for them.

For licensed clinicians. Use with clinical judgment. Statements are quoted from the FDA label; confirm against the label for the product you are using.